PACK-CXL is a therapeutic procedure that uses photo-activated chromophores against the pathogens involved in infectious keratitis. The penetration of the chromophores into the corneal stroma is conventionally achieved by corneal soaking with a Riboflavin solution for 30 minutes. Studies have shown that Riboflavin penetration can be enhanced by iontophoresis, a procedure consisting in applying an electrical current to an ionisable substance to increase its mobility across a surface.

The administration set IONTOFOR-VET uses this technology to enhance PACK-CXL procedure by reducing the soaking phase from 30 minutes to 5 min. No epithelium removal is needed.
IONTOFOR-VET is for veterinary use only.



IONTOFOR-VET must be used with the current generator I-ON CXL® for veterinary use and an ultraviolet light emitting source for ophthalmic use (UV-A; 370nm) with a power from 3mW/cm2 to 30mW/cm2, to deliver a total amount of 5,4 J/cm², with a beam diameter of 8 mm. Refer to the UVA emitting source list available in the tab “Products”.

Administration set

– Corneal applicator

Inside diameter: 9 mm.

Reservoir volume: 2 ml (1 ml functional).

– Ribovet solution

Riboflavin solution (0,1%)

Volume: 1,5 ml

Expiry date: 2 years

– Vacuum syringe

Direct current generator

Product subject to WEEE regulations concerning separate waste collection of electronic equipment
Class II device
European compliance (EMC standards and ROHS)
Applied part type BF
Manufacturing date (month/year)
</p> <p>Technical features
Classification:IP20 for water and dust penetration.
Power supply:9V battery, mod. 6LR61
Protection:Internal protections against polarity inversion and overload.
Output:Single channel.
Current:1.0mA max. on 1KOhm load. Device can deliver the set current on a load in the range of 0 to 40 KOhm, delivering a constant current dose of 5mA.min. Treatment time is automatically adjusted till the complete delivering of 5mA.min.
Waveform:Continuous current for iontophoresis treatment, 30 seconds increasing ramp. The current is constant over a load in the range 0 to 40 KOhm.
Display:Black digits, blue backlighted
Keyboard:DOSE SELECT and START/STOP button.
Dimensions:mm. 118 x 67 x 24.
Weight:280gr. Battery included</p> <p>

UVA emitting source

Opia doesn’t sell UVA emitting source. Find below some devices available on the market.

If you need more information about UVA emitting source or their distributors, contact-us using the contact form below.

Device Manufacturer Power (mW/cm2) Distribution link
VEGA CSO 3 or 10
UV-X 2000 AVEDRO 9
KXL AVEDRO 3 to 45
UV-360 NEW VISION INC. 10-90


1 IONTOFOR-VET administration set.

1 hypodermic needle, sterile (not supplied).

1 empty syringe Luer-lock, sterile (not supplied).

– 1 blepharostat (not supplied).

Generator, I-ON CXL® for veterinary use.

Ultraviolet light emitting source for ophthalmic use (UV-A; 370nm)


Administration set 


Direct current generator




  1. Patient under general anaesthesia, eye positioned horizontally.
  2. Blepharostat keeps the lids open.
  3. Insert the hypodermic needle subcutaneously at the temporal palpebral canthus or in the neck.


  1. Make sure the current generator ION-CXL® is switched off.
  2. Connect the current generator I-ON CXL® with the applicator and the return electrode (hypodermic needle).
  3. Position the applicator on the cornea and use the vacuum syringe to fix the applicator on the eye. Close the clamp.
  1. Fill the corneal applicator reservoir with RiboVet solution until the level is above the mesh electrode.

      Soaking phase

  1. Turn on the current generator, choose 1 mA and press START.
  2. The procedure should last 5 minutes. Avoid touching the applicator during the procedure.
  3. At the end of the treatment, remove the solution from the reservoir.
  4. Open the clamp and remove the applicator from the eye. Disconnect the current generator from applicator and hypodermic needle. Take off the hypodermic needle from the patient.
  5. Rinse the patient eye with a saline solution.

     Irradiation phase

  1. Proceed immediately with the irradiation using the UV-A emitter.
  2. Discard the corneal applicator, hypodermic needle and vacuum syringe according to standard operating procedures.

Download Instruction for use (PDF)

Consult instructions for further details

What means PACK-CXL ?

PACK means Photo Activated Chromophore for Keratitis. CXL means Cross-linking.

This term was defined at the 9th annual international CXL congress in 2013. In this procedure, the chromophores administered into the cornea are photo-activated with UV-A light and act as a disinfectant, reducing the pathogen load.

Which kind of animals can benefit of IONTOFOR-VET treatment ?

The device is adapted to most cats and dogs’ eye morphology. Studies are ongoing on other species. We can assume that the device is adapted for corneas with a diameter above 12,5 mm.

Is the administration set IONTOFOR-VET reusable?

No, the administration set IONTOFOR-VET shall be disposed after one use on a single eye. The direct current generator is reusable.

Is anesthesia needed?

Yes. Patient should be put under general anesthesia before treatment, with the eye to be treated to the horizontal, looking up.

Which electrical current shall be applied ?

The I-ON CXL generator was tailored to the procedure and delivers 1 mA for 5 minutes (or 0,5 mA for 10 minutes). The generator is reusable and supplied with a 9V battery.

Which UV- Light shall be used ?

The chromophore used is activated at a wavelength of 365 nm. The total dose of energy delivered shall be 5,4 J/cm2.

You have not found the answer to your question ?

Please contact us using the contact form or send us an email to

Publications in veterinary reviews about PACK-CXL outcomes in the treatment of melting keratitis.

Author Year description Source Link
Famose 2013 Evaluation of accelerated collagen cross-linking for the treatment of melting keratitis in ten cats Vet. ophthalmol
Famose 2013 Evaluation of accelerated collagen cross-linking for the treatment of melting keratitis in eight dogs Vet. ophthalmol
Hellander-Edman 2013 Corneal cross-linking in 9 horses with ulcerative keratitis BMC vet research
Pot 2013 Corneal collagen cross-linking as treatment for infectious and noninfectious corneal melting in cats and dogs: results of a prospective, nonrandomized, controlled trial Vet ophthalmol
Spiess 2014 Corneal collagen cross-linking (CXL) for the treatment of melting keratitis in cats and dogs: a pilot study Vet Ophthalmol
Famose 2014 Evaluation of accelerated corneal collagen cross-linking (cxl) after impregnation of riboflavin by iontophoresis for the treatment of melting keratitis in 6 cats. Forthcoming…  Forthcoming…
Famose 2015 Corneal collagen cross-linking: interests and applications in veterinary ophthalmology. Bull. Acad. Vét. France

Publications about the soaking of the cornea with riboflavin solution using iontophoresis method.

Author Year description Source Link
Arboleda 2014 Evaluating in vivo delivery of riboflavin with coulomb-controlled iontophoresis for corneal collagen cross-linking: a pilot study. Invest Ophthalmol Vis Sci
Cassagne 2014 Iontophoresis transcorneal delivery technique for transepithelial corneal collagen crosslinking with riboflavin in a rabbit model. Invest Ophthalmol Vis Sci
Mastropasqua 2014 Corneal cross-linking: intrastromal riboflavin concentration in iontophoresis-assisted imbibition versus traditional and transepithelial techniques. Am J Ophthalmol.
Stanca 2013 The use of iontophoresis in corneal crosslinking technique Oftalmologia
Bikbova 2013 Transepithelial corneal collagen cross-linking by iontophoresis of riboflavin. Acta Ophthalmol.
Famose 2014 Evaluation of accelerated corneal collagen cross-linking (cxl) after impregnation of riboflavin by iontophoresis for the treatment of melting keratitis in 6 cats. Forthcoming…  Forthcoming…
Famose 2015 Corneal collagen cross-linking: interests and applications in veterinary ophthalmology. Bull. Acad. Vét. France

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About US


Founded in January 2010 and based at the Vision Institute in Paris, OPIA Technologies is a company dedicated to the development of an innovative portfolio of medical devices for ophthalmology.

Our aim is to provide innovative and reliable devices to improve the care of patients with ocular diseases.

So far, OPIA has developed EYEPRIM™, a device to perform conjunctival impressions of the living eye, and IONTOFOR-VET, a device to improve the treatment of infectious keratitis in animals.

Opia meets the highest level of regulatory requirements with a quality assurance system certified ISO 13485.

Download Certificate ISO 13485 OPIA


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